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Accelerating an International Effort Led by UCSF to Identify Drug Targets for COVID-19

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As COVID-19 rapidly spread throughout the world, there became an urgent need for therapeutics to treat the infection.

Nevan Krogan, Ph.D., Professor and Director of UCSF’s QBI, quickly joined forces with an international team of scientists to map out the genome of SARS-CoV-2 and discover key interactions between the virus and over 300 human host proteins, as recently reported in Nature.

Synthego has joined this effort by leveraging its high throughput genome engineering capabilities to systematically knock these human genes out of a cell line model of infectivity - in order to validate these interactors and help identify novel and repurposed drug targets.

Learn More about UCSF’s QBI: https://qbi.ucsf.edu/qcrg

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing: https://www.nature.com/articles/s41586-020-2286-9

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